Ischemic Stroke

NeoNeuron has expertise in rodent (neonate, mice and rats) and non-human primate (NHP) models of hypoxic-ischemic brain injury and stroke.

NeoNeuron combines these models with non-invasive multimodal molecular imaging including positron emission tomography (PET), magnetic resonance imaging (MRI) and bioluminescence imaging approaches to investigate efficacy and safety profile of cells, genes or drug candidates in an OLAW and AAALAC accredited animal facility.

The NHP stroke model is highly recommended by the Stroke Program Review Group convened by the NIH and by the Stroke Therapy Academic Industry Roundtable (STAIR) for translational research to optimize critical parameters for the success of the therapeutic intervention in humans. Similarly to patients afflicted with stroke, the NHP model we use has well-defined anatomical infarct lesions and motor behavioral deficits in specific phases of movement execution and fine motor skills.